Endocrine Abstracts

Mice overexpressing growth hormone (GH) have about two-fold higher IGF-I and clear increases in body and organ weights. Moreover, administration of GH to hypophysectomised or dwarf mice has been shown to increase IGF-I. Data on the short term effects of exogenous administration of rhGH in normal rodents remain scarce.Therefore, we measured IGF-I before and after one week of GH-treatment in 10-week-old female mice, injected daily with two different doses ...

Scattered case reports have described patients who have been diagnosed with both primary hyperaldosteronism and prolactinoma. Prolactin receptor (PRLR) is known to be expressed in human adrenal cortex. Furthermore, PRLR mRNA and protein have both been detected in human adrenal tumors. It has also been shown that PRL treatment of adrenal cells is capable of stimulating aldosterone secretion. The contribution of PRL to the development of hyperaldosteronism is u...

Maintenance of ketosis and increases in resting energy expenditure (EE) are two proposed mechanisms for weight loss observed in humans performing low-carbohydrate/high-fat (LC-HF) diets like the Atkin’s diet. To explore these potential mechanisms, we pair-fed isocaloric amounts of regular chow (CH) or two LC-HF diets (carbohydrates~1%ME) to male Wistar rats for 4 weeks. LC-HF-1 (fat~66%ME) was matched in protein content to CH, whereas LC-HF-2 was even higher in fat (~94%M...